SKU: 3162844118

Kupfertoxikose (CT) - Labrador Retriever

Sale price$44.10 Regular price$49.00
Save 10%

Pay in installments of $12.25 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 20 - Jul 25

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Kupfertoxikose (CT) - Labrador RetrieverStoffwechselstrungen des Kupfers sind genetische Strungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren ATP7A und ATP7B. Der ATP7A Transporter ist entscheidend fr den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend fr den Kupferexport aus der Leber. Mutationen im ATP7A fhren zu einem defekten ATP7A Transporter, sodass das Kupfer nicht richtig aus

Stoffwechselstörungen des Kupfers sind genetische Störungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren – ATP7A und ATP7B. Der ATP7A-Transporter ist entscheidend für den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend für den Kupferexport aus der Leber. Mutationen im ATP7A führen zu einem defekten ATP7A-Transporter, sodass das Kupfer nicht richtig aus den Fibroblasten exportiert und in die Leber importiert werden kann, was zu einem Kupfermangel in der Leber führt. Dies führt zu Menkes-Krankheit, einer tödlichen neurodegenerativen Erkrankung, die durch zerebrale und zerebelläre Degeneration, Gedeihstörung, grobes Haar und Bindegewebsanomalien gekennzeichnet ist. Währenddessen führen die Mutationen im ATP7B-Gen zu einem defekten ATP7B-Transporter, sodass das Kupfer nicht richtig aus der Leber exportiert werden kann, was zu einer Kupferansammlung in der Leber und sekundär im Gehirn führt. Dies führt zu Morbus Wilson, was bei mittelalten Hunden zu Zirrhose und neuronaler Degeneration führt. Die Mutation im ATP7A-Gen hat eine X-chromosomale Vererbung und die Mutation im ATP7B-Gen hat eine unvollständig dominante Vererbung. Störungen treten bei Labrador Retrievern und Dobermann Pinschern auf. Bei Dobermann Pinschern werden jedoch Mutationen in beiden Genen gefunden, aber nur die Mutation im ATP7B kann zu einer Störung führen, in diesem Fall Morbus Wilson. Bei Labrador Retrievern können Mutationen nur in einem oder in beiden Genen gleichzeitig vorhanden sein. Mutationen in beiden Genen gleichzeitig können zu einer abnorm hohen Kupferansammlung führen, die zu Kupfertoxikose führt, insbesondere bei Hündinnen.

Vererbung: komplex

Mutation: ATP7A und ATP7B Gen

Gentest: Die Methode, die für den Gentest verwendet wird, ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 3162844118

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.6 ★★★★★
Based on 28 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
S
Verified Purchase
Simm in Seattle
Pawtucket, US
★★★★★ 3
Engaging and Fun, But Lacks Durability for Strong-Gripped Dogs
Color: Green
The internal mechanism of this toy works very well, and the ball’s movement immediately caught the attention of my Boxer pup. He was absolutely fascinated and spent hours each day playing with it. However, while the toy’s design is engaging, the durability of the exterior leaves much to be desired—especially for dogs who tend to pick things up with a firm grip. We didn’t know what to expect since our pup hadn’t previously played with an interactive ball, so we supervised playtime and made sure to store the ball in a safe spot when we couldn’t keep an eye on him. Despite this, the ball didn’t hold up. Our pup wasn’t intentionally chewing it. He simply carried the ball in his mouth when we moved downstairs or to another room, yet the grip while he carried the ball caused significant damage to the exterior. Within about a week of regular use (approximately 40 hours in total), the ball’s outer layer became deeply gouged by his teeth. To clarify, my pup wasn’t biting down hard or trying to destroy it, but his natural grip while carrying the ball left deep grooves in the surface. In just days, these gouges made the exterior sharp to the touch and compromised the structure. By the end of the week, we couldn’t screw the cover back together after removing it to recharge the ball, which made it unusable. And I was dismayed that there aren’t replacements readily available. Overall, my pup absolutely loved this toy — it was engaging and kept him entertained for hours. However, if your dog has a strong grip or frequently carries toys in their mouth, this may not hold up as well as expected. It’s a great concept but needs a more durable outer layer and replacement hard covers to make it a long-term investment.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 3, 2025
L
Verified Purchase
Larry Z.
Whiting, US
★★★★★ 5
My dog loves this ball
Color: Green
The battery on this lasts forever. The random on/off motion and when it gets touched inducing motion just keeps my dog guessing and occupied for a long time. My dog's tail is wagging the whole time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
D
Verified Purchase
DM
Birmingham, US
★★★★★ 5
Great ball
I have bought two of these in different colors. My Yorkie loves them. They’re very interactive even if you don’t put the cover on it they move and if he’s not playing with it, it tends to go into sleep mode.My Yorkie got the cover off the ball within the first two minutes. But he loves the ball. Now bought 2nd ball. The ones with covers don’t work he rips the covers off.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 15, 2025
L
Verified Purchase
Lindsey Newhouse
Charlottesville, US
★★★★★ 5
Super Fun
Color: Green
One of the most entertaining things you could buy. The dogs go crazy over it and have so much fun. It's a bit loud on hard floors, but honestly worth it for the laughs. Seems pretty durable too. I have 2 labs; one started out uninterested and the other started off scared of it, but not too long after, they both started going crazy, tossing and carrying it around while it shook.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 21, 2026
M
Verified Purchase
Monica
Grantham, US
★★★★★ 4
Great customer service
Bought this for our dog for Christmas! He loved it! It sadly stopped working shortly after. Recently emailed the product site themselves and they sent a new one that week! Great customer service and great toy!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 25, 2026

recommand products