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Description
CDH17/LI-cadherin His Tag Protein, HumanProduct Specification Species Human Synonyms Liver intestine cadherinHPT 1CDH16Intestinal peptide associated transporter HPT 1LI cadherinHPT 1 CadherinCadherin 17 LI Cadherin (Liver Intestine)HPT1Human Intestinal Peptide Associated Transporter HPT 1LI CadherinCadherinCadherin 17Human Peptide Transporter 1Cadherin 16 Accession Q12864 Amino Acid Sequence Gln23 Met787, with C terminal His Expression System HEK293 Molecular Weight 95 110kDa (Reducing)
Product Specification
| Species | Human |
| Synonyms | Liver-intestine cadherin，HPT-1，CDH16，Intestinal peptide-associated transporter HPT-1，LI-cadherin，HPT-1 Cadherin，Cadherin 17， LI Cadherin (Liver-Intestine)，HPT1，Human Intestinal Peptide-Associated Transporter HPT-1，LI Cadherin，Cadherin，Cadherin 17，Human Peptide Transporter 1，Cadherin-16 |
| Accession | Q12864 |
| Amino Acid Sequence | Gln23-Met787, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63. |
Background
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. It's also involved in intestinal peptide transport.
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