SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

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Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


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SKU: 87097093269

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4.2 ★★★★★
Based on 6 reviews
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Preston G. Johnson
Carnegie, US
★★★★★ 5
Convenient
Size: 01- 24pcs (Classic Green)
Very nice kit with everything in one zippered pouch.
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Reviewed in the United States on May 28, 2026
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ZERO COOL
Houston, US
★★★★★ 5
A Lifesaver on the Road!
Size: 01- 24pcs (Classic Green)
I recently purchased the Tire Repair Kit with 24 pieces, and it has proven to be an absolute lifesaver for various vehicles, including my car and motorcycle. This kit is a must-have for anyone who wants to be prepared for unexpected flat tires. The variety of tools provided is impressive, making it suitable for different tire types and sizes, from cars and motorcycles to ATVs, trucks, and even tractors. The comprehensive nature of the kit instills confidence that you'll have the right tool for the job in any situation. The quality of the tools is top-notch. The plugs and patches adhere securely and provide a reliable and durable fix. The clear and concise instructions included in the kit make the repair process straightforward, even for those who are not mechanically inclined. The compact and well-organized carrying case ensures that all the components are easily accessible and stay in excellent condition. I appreciate the portability of the kit, making it convenient to store in the trunk of my car or with my motorcycle gear. Having used this kit in an emergency, I can attest to its effectiveness. It saved me from the hassle and expense of calling for roadside assistance. For anyone who values self-sufficiency and being prepared on the road, I highly recommend the Tire Repair Kit. It's a small investment that provides tremendous peace of mind!
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Reviewed in the United States on February 23, 2024
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Verified Purchase
Atesia Telles
Houston, US
★★★★★ 5
WORTH IT!!
Size: 16 Fl Oz (Pack of 1), Style: Fresh
After debating for a few weeks, I finally bought this interior cleaner hoping it would be better than the other stuff I had been using. I just got a new vehicle and really want to keep it detailed and nice. This stuff is FANTASTIC!! It made the whole cleaning process easier. I am a mom to 6 kids and between everyday school trips and busy sports seasons, the dirt and wear can add up QUICK. I needed something worth the money and to make my cleaning process easier and worth my time in this very busy season of life. It leaves a nice finish without any streaks or oily appearance. It dried in a timely manner and my Suburban looks and smells wonderful.
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Reviewed in the United States on May 3, 2026
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Verified Purchase
Cat B
New York, US
★★★★★ 5
Nice Interior Cleaner / No Residue and No Shine
Size: 16 Fl Oz (Pack of 1), Style: Fresh
Most people knock Chemical Guys and it appears a rather basic , not boutique, car care line. This is one hit in the line and actually comes in at least three versions based upon the scent left after use. This one is a baby powder scent that does not linger too long nor to heavy. The cleaning power is light with no streaks. It dries quickly and does not appear to leave any markings. A light spritz on doors, dash, and interior parts and a quick wipe with MF. You could use a dampen towel also. It leaves behind no shine or dressing afterwards which is wonderful for those wanting a fresh like new appearance without the shine or goopy sticky mess.
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Reviewed in the United States on May 25, 2026
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MH
Houston, US
★★★★★ 5
Very nice look and perfect "sheen"..
Size: 16 Fl Oz (Pack of 1), Style: Fresh
I've been an avid detailer for 30 years. And I do love the chemicals aspect of it. I've tried many products, and the vast majority of them aren't very good. Mind you, I was starting out detailing back in the 80's, when you had a VERY limited amount of products to rely on (And yes, I remember the very first days of Armor-All when it would CRACK your dash.. Those days are, of course, long gone. But I have been a big fan of Chemical Guy's products, and have written many reviews on here about their other products. This Total Interior, I have to say, has met or exceeded my expectations. Tip and note: Always wear nitrile type gloves whenever using any chemicals for detailing, repair, etc A garage isn't complete without nitrile gloves and an air compressor.. Enough on that. First off, they say you can use it on glass, and this would replace a lot of other cleaners and protectants, I'm not sure I would use anything to clean glass other than Invisible Glass. I've tried them all, and to me, Invisible Glass is my go-to and ONLY glass cleaner. Secondly, this DOES have a UV protectant in it, which of course, led me to purchase this. I've said on here before that if you are going to take the time to detail, and make the effort, you should not waste your time with products (Especially interior products) that don't protect the interior from UV damage.. The sun is a killer on leather and plastic.. (And paint, over time).. So if you're going to use any products on your interior make sure they have UV protectants. Thirdly, they say you can use this on Leather. I for one, after working with it, probably wouldn't use it on my leather, I prefer some other products for that, and yes, don't bother using ANY leather treatment unless it has a UV protectant in it, or at least follow it up with something that DOES have a UV protectant. I personally wouldn't use this on my leather. I would use Chemical Guys' Sprayable Leather Cleaner and Conditioner (no UV protectant), and then follow it with Klasse Interior as the Klasse has a UV protectant. The Klasse is also a water based formula (The original was oil based) and it also helps to tighten the leather a bit too.. Those two in combination make a nice look. What's nice about this Total Interior Cleaner Protectant (TICP) is the way it goes on. You want to use a fairly deep piled Microfiber cloth to apply it. Pre wet the cloth with distilled water in a spray bottle. Spray the TICP generously on the interior doors and plastics. It works especially well cleaning off your armrests and control modules for windows, door locks. I would generously spray it on the door panels and work it in, but I would not spray it directly on my speaker grills or into the control buttons, you want to work around that. For those areas, after you do the general door panels, or interior, and then come back and spray on your towel, and then hit the specific areas. For the front dash, and the LCD screen, I sprayed onto my pre moistened towel, worked it in nicely, then I quickly grabbed another microfiber towel that didn't have a "pile" on it. Almost like those microfiber dishtowels. The reason why is when you go for that quick buff (And just a quick buff, that's all you need) you can and will create some static.. And when you create that static you'll break off peach fuzz off a piled microfiber cloth and it may stick due to the static. So use a microfiber towel with no pile on it and quickly buff it, you don't need much, this product is "hot" and dries fairly quickly, a couple swipes, that's it. I did get the baby oil scent, and it's reminiscent of that, but not too strong or overdone. A nice fragrance. It comes in a couple other scents. The final look is very nice, it's not a shine or a heavy sheen, it's in between the OEM flat look (When you first purchase a new car) and a light satin. Just enough sheen to spruce up the interior, but not like a basted turkey that looks greasy or oily. Just right.
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Reviewed in the United States on January 15, 2024

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